Managing SARS-CoV2 Infections Through Resolution of Inflammation by Eicosanoids: A Review

Managing SARS-CoV2 Infections Through Resolution of Inflammation by Eicosanoids: A Review

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Ameena Mohammed,1 Arunasree M Kalle,2 Pallu Reddanna2 1Department of Biological Science, Indian Institute of Science Education and Research Kolkata, Nadia, West Bengal, 741246, India; 2Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, IndiaCorrespondence: Pallu Reddanna; Arunasree M Kalle, Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, TS, 500046, India, Tel +91 4023134542, Fax +91 4023134120, Email [email protected]; arunasreemk@uohyd.

ac.inAbstract: Severe Corona Virus Disease is characterized by angiocentric inflammation of lungs and cytokine storm leading to potentially fatal Mandolines multiple organ failure.Several studies have shown the high levels of pro-inflammatory cytokines, indicative of a poor prognosis in COVID-19.

Eicosanoids play an important role in the induction of inflammation and cytokine production, while anti-inflammatory and pro-resolving properties of some eicosanoic acid derivatives enable inflamed tissues to return to homeostasis through the resolution of inflammation by aiding the clearance of cell debris 406 and downregulation of pro-inflammatory stimulants.This review attempts to provide an overall insight on the eicosanoids synthesis and their role in the resolution of inflammation in the context of Corona Virus infection.Keywords: COVID-19, lipid mediators of inflammation, polyunsaturated fatty acids, cyclooxygenases, lipoxygenases, cytochrome P450, eicosanoids.